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Cometriq Thyroid Approval May Open Door For Use In Prostate Cancer

 
• By Emily Hayes

As cabozantinib wins FDA approval for the rare medullary thyroid cancer, Exelixis stresses its broader development program in other tumor types, notably prostate cancer. The company is likely to submit prostate cancer data to compendia, which if successful could enable reimbursement for the off-label use.

Exelixis Inc.is expected to submit positive trial data for Cometriq (cabozantinib) in prostate cancer to the national drug compendia, a move – following the drug’s approval in rare medullary thyroid cancer – that could enable use and reimbursement in a much larger indication prior to formal clearance.

Cometriq is an oral inhibitor of several kinases including MET, RET and VEGFR2. On Nov. 29, the drug cleared FDA for progressive, metastatic medullary thyroid cancer, a very rare kind...

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