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Signifor Approval Highlights Success Of Novartis’ Parallel Development Strategy

Following its approval in Europe earlier in 2012, the FDA approval of Signifor for Cushing’s disease is just the latest piece of a strategy to bring the injectable to market in multiple indications, including acromegaly.

With its FDA approval for Cushing’s disease, Novartis AG’s Signifor (pasireotide) is now cleared in both the U.S. and Europe as the first drug for the orphan condition. But Cushing’s is just part of the pharma’s strategy for pasireotide – it also plans to file for approval in acromegaly in 2013 and later for carcinoid neuroendocrine tumors.

The approach being used with pasireotide is a parallel development strategy that CEO Joe Jimenez has credited with helping Novartis to reduce drug-development timelines. During Novartis’ Nov. 8 R&D day, Jimenez noted that back in 2007 when the company was in dire straits due to the patent expiration of Diovan (valsartan), it was moving forward with a new R&D strategy within its Novartis Institute for Biomedical Research

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