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Should PD-L1 Expression Be Used As A Biomarker For Immunotherapy?

 
• By Emily Hayes

Oncologists’ distrust of the PD-L1 biomarker was more evident at ASCO than ever. Regardless of what “marketing people” might want, immunotherapy demands more than a single biomarker, MD Anderson GU specialist Padmanee Sharma tells a packed audience on opening day. >>>Listen in to an audio clip of Genentech’s Ira Mellman discussing the company’s view.

In a repeated refrain at the 2014 American Society of Clinical Oncology meeting, leading doctors suggested that limiting treatment with new immune checkpoint inhibitors to those who test positive for the PD-L1 biomarker could be unfair and unethical.

The recent ASCO annual meeting, held in late May/early June, provided an opportunity for anti-PD-1 and anti-PD-L1 antibodies to shine in new tumor types, including lung, bladder and head and...

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