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Positive Early Results For Addex Parkinson’s Drug Dipraglurant Spur Hopes For Deal

 
• By Emily Hayes

In a small, short Phase IIa study, an oral inhibitor of mGluR5 proved effective at reducing dyskinesia caused by levodopa. If future trials are positive, the drug would have a significant positive impact on Parkinson’s patients, says the Michael J. Fox Foundation.

Addex Therapeutics’ successful Phase IIa study of dipraglurant (ADX48621) builds on a body of evidence supporting mGluR5 as a target for dyskinesia caused by the standard of care generic Parkinson’s treatment levodopa, and it may help the Swiss biotech attract a partner.

The market for Parkinson’s disease is largely dominated by generics, including levodopa Also see "Parkinson’s Disease At A Crossroad: Deals And Emerging Therapeutics" - Pink Sheet, 13 June, 2011.

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