CHICAGO––Roche/Genentech Inc.may hold off on an ovarian cancer filing for its VEGF inhibitor Avastin (bevacizumab) even though it now has data from four positive Phase III trials, including the AURELIA study in hard-to-treat platinum-resistant patients presented at the American Society of Clinical Oncology meeting June 2. In part because of its experience with the now-withdrawn breast cancer indication, the company is signaling it may wait for overall survival data.
The first study of Avastin in ovarian cancer, GOG-0218, debuted at ASCO in 2010, followed quickly by ICON-7. At that...