GSK/ChemoCentryx Crohn’s Failure May Sink Hefty Phase III Program

SHIELD-1 failure puts the entire 2,500-patient plus Phase III clinical program in limbo as GSK rethinks its Crohn’s disease approach and partner ChemoCentryx’s stock loses close to half its value.

Just a week after the approval for the HIV therapy Tivicay under GlaxoSmithKline PLC’s joint venture with Pfizer Inc.ViiV Healthcare – GSK’s plans for a surge in new drug launches hit a snag with the Phase III failure of the pharma giant’s oral Crohn’s disease therapy vercirnon, licensed from ChemoCentryx Inc.

Vercirnon, a specific CCR9 chemokine receptor inhibitor, was on a list of assets that GSK has pointed to as early...

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