Third-Generation EGFR Inhibitors’ Safety Profiles Under Scrutiny At ASCO

In stark contrast with the first generation of EGFR inhibitors, Clovis’ CO-1386 has rash rates that are on par with placebo. But the drug must contend with high rates of excess blood sugar as well as QTc prolongation. AstraZeneca’s AZD9291 has its own safety issues, but coming efficacy results should carry the class.

CHICAGO – The early data on the next generation of epidermal growth factor receptor inhibitors, including drugs from Clovis Oncology Inc., AstraZeneca PLC and Hanmi Pharmaceutical Co. Ltd., suggest significant advances in safety and efficacy over their predecessors in lung cancer, but individual side effect profiles could help differentiate the newcomers.

Results from studies of early stage studies in relapsed/refractory EGFR+ non-small cell lung cancer patients of Clovis’ CO-1686, AstraZeneca’s AZD...

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