AstraZeneca Scores Lung Cancer Touchdown, While Clovis Fumbles

Both AstraZeneca’s Tagrisso and Clovis’ rociletinib target metastatic EGFR T790M mutation-positive non-small cell lung cancer. Tagrisso was approved by FDA Nov. 13, while Clovis said its drug would be delayed because mature data showed fewer confirmed responses than earlier data.

AstraZeneca PLC has gained a significant lead over Clovis Oncology Inc. in their long-standing race to come to market with competing drugs targeting metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive non-small cell lung cancer. AstraZeneca’s Tagrisso (osimetinib) cleared FDA just before Clovis announced a delay for its rociletinib.

FDA approved AstraZeneca’s Tagrisso, previously known as AZD9291, Nov. 13, well ahead of the February user fee deadline. The agency...

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