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Teva/Xenon’s Pain Ointment Failure Leaves Sparser Nav1.7 Pipeline

 
• By Emily Hayes

Once highly anticipated as an alternative mechanism for pain, the Nav1.7 target suffered another blow with Teva/Xenon’s failure of TV-45070 in osteoarthritis, though the class may still work in neuropathic pain.

The Phase IIb failure of Teva Pharmaceutical Industries Ltd./Xenon Pharmaceuticals Inc.’s TV-45070 pain ointment in osteoarthritis is another blow for the once very promising Nav1.7 target, but some consultants advise not to rule the class out yet in other indications.

TV-45070 is a small molecule inhibitor of the sodium channel Nav1.7 and other sodium channels, including those that are expressed...

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