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Teva Faces Laquinimod Setback After High Dose Linked To CV Events

 
• By Jessica Merrill

Teva will discontinue higher doses of laqunimod in two ongoing studies for multiple sclerosis after cardiovascular events were experienced in eight patients. Trials will continue with a lower dose.

Teva Pharmaceutical Industries Ltd.’s attempt to produce greater efficacy with the investigational multiple sclerosis drug laquinimod by testing higher doses has backfired. The company revealed Jan. 4 that it will discontinue higher doses of laquinimod in two ongoing clinical trials after eight non-fatal cardiovascular events occurred.

The two trials, CONCERTO and ARPEGGIO, will continue testing the lower 0.6 mg dose, where no cardiovascular events have been...

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• By Eliza Slawther

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Adaptive Clinical Trials Require ‘Clear And Compelling Justification’

 
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