Teva Faces Laquinimod Setback After High Dose Linked To CV Events

Teva will discontinue higher doses of laqunimod in two ongoing studies for multiple sclerosis after cardiovascular events were experienced in eight patients. Trials will continue with a lower dose.

Teva Pharmaceutical Industries Ltd.’s attempt to produce greater efficacy with the investigational multiple sclerosis drug laquinimod by testing higher doses has backfired. The company revealed Jan. 4 that it will discontinue higher doses of laquinimod in two ongoing clinical trials after eight non-fatal cardiovascular events occurred.

The two trials, CONCERTO and ARPEGGIO, will continue testing the lower 0.6 mg dose, where no cardiovascular events have been...

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