More Than CAR-T: Hematologic Oncology Pipeline Offers Rich Menu Of Possible Approvals

Sponsors of established products like Amgen's Kyprolis and Blincyto and Bristol's Sprycel work to bulk up labeling with new indications while FDA reviews at least six novel agents for blood cancers.

Destruction of leukaemia cell, conceptual image. 3D illustration which can be used to illustrate blood cancer treatment

Excitement over emerging chimeric antigen receptor T-cell (CAR-T) therapies has put hematologic oncology in the headlines, but FDA's blood cancer reviewers are also busy with a full pipeline of new agents – including at least six new molecular entities and novel biologics with user fee in goals in 2017 – as well as the line extensions and expanded indications collecting around the agents that were novel in the recent past.

New hematologic cancer agents under review represent a high level of both novelty and medical advances. The individualized CAR-T candidates from Novartis AG and Kite Pharma Inc. both carry breakthrough therapy designations (BTDs), as do Pfizer Inc

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