Xeljanz Doesn't Improve Radiographic Progression In Psoriatic Arthritis. Does It Matter?

 
• By Derrick Gingery

Pfizer's JAK inhibitor met its co-primary efficacy endpoints, but US FDA still wants discussion of lack of impact on radiographic progression.

FDA entrance sign 2016

Pfizer Inc. may have to overcome a lack of improvement on an endpoint typically not required for approval if it is to gain a psoriatic arthritis indication for Xeljanz (tofacitinib).

If it gets the expanded indication, the Janus associated kinases (JAK) inhibitor would be the first in its class with...

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