Mylotarg Returns: US FDA Approves Pfizer's Leukemia Drug With Bonus Pediatric Indication

Agency's Oncologic Drugs Advisory Committee had only discussed gemtuzumab as a treatment for adults with acute myeloid leukemia at its July meeting, but labeling includes a pediatric claim based on a 29-patient trial; drug returns to the US market after being withdrawn in 2010 for failure to confirm clinical benefit.

Pfizer Inc.'s acute myeloid leukemia (AML) drug Mylotarg (gemtuzumab ozogamicin) is heading back to the US market after being withdrawn in 2010, and FDA's re-approval comes with a bonus pediatric indication that was not discussed at a July advisory committee meeting.

FDA approved Mylotarg Sept. 1 for the treatment of adults with newly diagnosed AML whose tumors express the CD33 antigen, an indication for which the Oncologic Drugs Advisory Committee (ODAC) said the drug demonstrated a favorable risk/benefit profile

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