Vyleesi Reviewers

US FDA staff who participated in the review and approval of AMAG’s bremelanotide for hypoactive sexual desire disorder.

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Updated: Makary Backs New Novavax COVID-19 Trial, Political Officials Take Over Product Review

 

In an unusual move, Tracy Beth Høeg, a special assistant to FDA Commissioner Martin Makary, is leading the continued negotiations on Novavax’s delayed COVID-19 vaccine approval.

Mesoblast’s Ryoncil: US FDA Changed Its Mind On Need For A Randomized Trial

 
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Agency staff repeatedly said the BLA based on a single-arm study in 55 patients lacked substantial evidence of effectiveness in steroid-refractory acute graft-versus-host disease and a randomized trial was needed, but changed course “based on additional consideration” after a second CRL.

Ryoncil Chronology: Three Review Cycles, Two CRLs, One Dispute Resolution Request

 
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The Pink Sheet’s Drug Review Profile looks at the timeline for the clinical development and US FDA review of Mesoblast’s remestemcel for graft-versus-host disease.