The UK's National Institute for Health and Care Excellence (NICE) has for the second time recommended against making Janssen's antidepressant spray Spravato (esketamine) available on England's National Health Service.
NICE initially issued for consultation in January a draft guidance that said it could not recommend the drug for routine use on the NHS for patients with treatment-resistant depression because of uncertainties about the product's clinical and cost effectiveness. In a new
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