Nuplazid Complete Response Letter For Dementia Psychosis Driven By Effectiveness Concerns In Subgroups

Acadia says the US FDA’s view has shifted from what was previously agreed upon for approval of an sNDA for pimavanserin in a broad dementia-related psychosis indication.

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Acadia's Nuplazid expansion plans were halted by FDA • Source: Alamy (LAMB / Alamy Stock Photo/Alamy Stock Photo)

ACADIA Pharmaceuticals Inc. is complaining that the US Food and Drug Administration has moved the goal posts for expanding the indication of Nuplazid (pimavanserin) into a broad population of patients with dementia-related psychosis (DRP).

Receiving a complete response letter (CRL) wasn’t a surprise, given that the company announced a delay in March due to deficiencies in the supplemental new drug application, but the scope of the requests outlined

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