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EMA Reviewing Cardiovascular & Cancer Risk From Five Janus Kinase Inhibitors

 
• By Neena Brizmohun

The European Medicines Agency has been asked to make a recommendation by 30 September on whether the marketing authorization for the products concerned should be maintained, varied, suspended or revoked.

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A review into the safety of five JAK inhibitors has started • Source: Alamy

The European Medicines Agency is starting to review the safety of five EU-approved Janus kinase (JAK) inhibitors that are used to treat chronic inflammatory disorders, due to concerns over an increased risk of developing a cardiovascular problem and cancer.

The safety review will focus on Xeljanz (tofacitinib) and Cibinqo (abrocitinib), both from Pfizer, and Jyseleca (filgotinib), Olumiant (baricitinib)...

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