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Sayonara, Yamagata: US Seasonal Flu Vaccines Shift From Quadrivalent To Trivalent For 2024-2025

 
• By Sue Sutter

New US formulations will contain only one B virus antigen after shedding the B/Yamagata component, a strain that has not been detected in circulation since March 2020. However, some US manufacturers will continue to produce quadrivalent vaccine for use in other countries, which have been slower to transition to trivalent.

Car wheels
Wheels are in motion for a global change to trivalent seasonal flu vaccine, with the US leading the way. • Source: Shutterstock

Only trivalent versions of seasonal influenza vaccine will be available in the US for the 2024-2025 season following the recommended removal of one of the B virus strains from formulations for domestic use.

However, some formulations produced domestically for use outside the US will still contain four virus strains for the coming Northern Hemisphere flu season.

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