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Lilly’s Kisunla: Labeling Allows For Stopping Treatment Based On Amyloid Plaque Reduction

 
• By Sue Sutter

However, the US FDA’s approval of donanemab comes with little guidance on when to stop treatment or when the anti-amyloid agent may need to be restarted in Alzheimer’s patients.

Stop light
Patients may stop taking Kisunla when amyloid plaque is reduced to 'minimal levels' on PET imaging. • Source: Shutterstock

US labeling for Eli Lilly and Company’s Alzheimer’s drug Kisunla (donanemab-azbt) allows for treatment cessation upon clearance of amyloid plaque, but offers little guidance on how to do that or when the drug may need to be restarted.

Key Takeaways

  • The FDA approved Lilly’s donanemab with labeling that states providers may consider stopping dosing based on a reduction of amyloid plaques to minimal levels in PET imaging.

“Consider stopping dosing with Kisunla based on reduction of amyloid plaques to minimal levels on amyloid PET imaging,” labeling...

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