ECHA: Registrants Using Skin Sensitization Alt Methods Should Update Dossiers Using OECD 497

The agency is aware of more than 14,000 substances on the EU market with some indication of skin-sensitization concern. Using the OECD guideline, adopted in June, registrants may be able to make conclusive predictions without use of animals and should update REACH dossiers accordingly.

Guinea Pig
• Source: Shutterstock

The European Chemicals Agency affirms that skin sensitization – a chemical safety endpoint that historically could not be assessed without animal testing – can be predicted using specific combinations of in silico, in chemico, and in vitro data.

“This is an important milestone for advancing the use of alternative methods to assess chemical hazards. With the new guideline, we make sure that this approach can be used to...

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