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CONCERT's over: Pfizer and Medivation drop Alzheimer's candidate Dimebon

 
• By Eleanor Malone

Pfizer and Medivation have dropped all further development of Dimebon (latrepirdine) after it failed to reach the two primary endpoints in the Phase III CONCERT trial in Alzheimer's disease. There had once been high hopes for the candidate, but disappointing results from earlier studies in Alzheimer's and Huntington's disease meant that this result had been widely anticipated.

Pfizer and Medivation have dropped all further development of Dimebon (latrepirdine) after it failed to reach the two primary endpoints in the Phase III CONCERT trial in Alzheimer's disease. There had once been high hopes for the candidate, but disappointing results from earlier studies in Alzheimer's and Huntington's disease meant that this result had been widely anticipated.

The CONCERT trial examined the use of Dimebon when added to ongoing treatment with Pfizer/Eisai's AChE inhibitor Aricept (donepezil) in...

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