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Alnylam and The Medicines Co run PCSK9 race together through $205m alliance

 
• By Mandy Jackson

With an exclusive global alliance worth up to $205 million plus double-digit royalties to develop and commercialize Alnylam Pharmaceuticals' ALN-PCS, the RNAi specialist and The Medicines Company are in a crowded field of companies with hypercholesterolemia therapies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9), which regulates low-density lipoprotein (LDL).

With an exclusive global alliance worth up to $205 million plus double-digit royalties to develop and commercialize Alnylam Pharmaceuticals' ALN-PCS, the RNAi specialist and The Medicines Company are in a crowded field of companies with hypercholesterolemia therapies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9), which regulates low-density lipoprotein (LDL).

The partners have a long way to run to catch up with the seven antibody developers that are developing PCSK9 inhibitors to lower LDL cholesterol, including two Phase III assets: Amgen's AMG-145 and REGN-727/SAR-236553 by Regeneron Pharmaceuticals and Sanofi (scripintelligence

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