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Infinity will not go beyond Phase II with retaspimycin

 
• By Mandy Jackson

Infinity Pharmaceuticals ended development for its selective heat shock protein 90 (Hsp90) inhibitor retaspimycin hydrochloride following a failed Phase II lung cancer study and will focus instead on IPI-145, an oral inhibitor of phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma.

Infinity Pharmaceuticals ended development for its selective heat shock protein 90 (Hsp90) inhibitor retaspimycin hydrochloride following a failed Phase II lung cancer study and will focus instead on IPI-145, an oral inhibitor of phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma.

It's the company's second failed drug in 15 months and the decision not to pursue additional retaspimycin studies leaves Infinity with one candidate in the clinic. The Cambridge, Massachusetts-based company...

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