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Onconova sinks on 2nd Phase III rigosertib bust

 
• By Mandy Jackson

Onconova Therapeutics plunged 37.4% in after-hours trading to $8.68 per share on 19 February after the company said its PI3K and PLK inhibitor rigosertib failed in the Phase III ONTIME clinical trial in high-risk myelodysplastic syndromes (MDS).

Onconova Therapeutics plunged 37.4% in after-hours trading to $8.68 per share on 19 February after the company said its PI3K and PLK inhibitor rigosertib failed in the Phase III ONTIME clinical trial in high-risk myelodysplastic syndromes (MDS).

It was the second late-stage failure for rigosertib in two months. The Newtown, Pennsylvania-based company discontinued a Phase III pancreatic cancer trial in December after the study's data safety monitoring board said rigosertib was unlikely to provide a statistically significant improvement in median overall survival (scripintelligence.com,

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