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Bristol-Myers commits up to $1.2bn in CytomX deal

 
• By Mandy Jackson

CytomX Therapeutics will get a $50m upfront payment from Bristol-Myers Squibb and is eligible to receive up to $1.2bn in milestone fees plus research funding and royalties under an agreement to discover, develop and commercialize novel immunotherapies.

CytomX Therapeutics will get a $50m upfront payment from Bristol-Myers Squibb and is eligible to receive up to $1.2bn in milestone fees plus research funding and royalties under an agreement to discover, develop and commercialize novel immunotherapies.

The deal announced on 27 May is one of a growing number of collaborations meant to bolster the BMS immuno-oncology pipeline, which includes the approved melanoma treatment Yervoy (ipilimumab) and...

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ASCO: AstraZeneca Changes Management Of Breast Cancer Resistance With SERENA-6

 
• By Mary Jo Laffler

AstraZeneca presented data from the SERENA-6 trial that experts said could represent a significant change in how HR+/HER2- breast cancer is treated.

ASCO: Rusfertide Inches Toward FDA Filing With Positive 32-Week Data

 
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ASCO: Trodelvy First-Line TNBC Data Seen As Potentially Practice-Changing

 
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Gilead chief medical officer Dietmar Berger said in an interview that the company plans to quickly take the results to regulators and foresees broad first-line use of the drug.

ASCO: Merck’s Zilo-V Shows Activity, But Numbers Still Small

 
• By Alaric DeArment

The drug boosted overall responses on top of the R-GemOx backbone, but the discussant pointed out that patients in waveLINE-003 were not very heavily pretreated.

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ASCO: Trodelvy First-Line TNBC Data Seen As Potentially Practice-Changing

 
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ASCO: Merck’s Zilo-V Shows Activity, But Numbers Still Small

 
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Summit’s Ivonescimab Shows Significance On PFS, But Not Overall Survival

 
• By Joseph Haas

In a study intended to show similar benefit in western patients, PD-1/VEGF-targeting ivonescimab met a progression-free survival endpoint, but missed on OS.