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ASH 2014: Mixed results for PD-1, CAR-T in blood cancers

 
• By Mandy Jackson

The 56th American Society of Hematology (ASH) Annual Meeting and Exposition from 6 to 9 December in San Francisco will give immunotherapy developers a chance to present efficacy (or lack thereof) in hematological malignancies after a fairly strong showing at this summer's American Society of Clinical Oncology (ASCO) conference (scripintelligence.com, 5 June 2014).

The 56th American Society of Hematology (ASH) Annual Meeting and Exposition from 6 to 9 December in San Francisco will give immunotherapy developers a chance to present efficacy (or lack thereof) in hematological malignancies after a fairly strong showing at this summer's American Society of Clinical Oncology (ASCO) conference (scripintelligence.com, 5 June 2014).

Abstracts for programmed cell death-1 (PD-1) inhibitors and chimeric antigen receptor T-cell (CAR-T) therapies became public on 6 November, giving...

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China’s Mid-Cap Companies Thriving On Big Pharma Deals

 
• By Andrew McConaghie and Edwin Elmhirst

Big pharma is increasingly looking east to restock its pipelines, a process that is helping to forge a new generation of mid-sized R&D-based companies in China and is reflected in their stock price performance.

Glenmark Chief On IGI’s Landmark Trispecific Deal: Strong Data Excited AbbVie

 
• By Anju Ghangurde

Glenmark’s managing director talks about IGI’s billion dollar-plus deal with AbbVie, ISB-2001’s striking data, the BEAT platform, other "exciting" pipeline assets and the "blood, sweat and tears" to get to this stage.

Four Chinese Firms Snag Global First-In-Class Approvals In China

 
• By Dexter Jie Yan

Four Chinese companies have won approvals in China, the first anywhere, for novel drugs for diffuse large B-cell lymphoma, certain types of non-small cell lung cancer and influenza A.

AbbVie Licenses IGI’s ISB 2001 In Second Myeloma Trispecific Deal For 2025

 
• By Alaric DeArment

IGI CEO Cyril Konto said in an interview that his company picked AbbVie for its agility, drug development acumen and expertise in areas like intellectual property and legal affairs.

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Phase III Success For AstraZeneca’s $5bn Hypertension Hope Baxdrostat

 
• By Andrew McConaghie

Rivals Mineralys could be first to file but AstraZeneca is banking on its cardiovascular market know-how to lead the emerging class.

Leo Lands Another Big Pharma Pact With Boehringer Spevigo Deal

 
• By Kevin Grogan

Paying €90m upfront for rights to generalized pustular psoriasis drug.

Capricor Gets Complete Response For DMD Cell Therapy

 
• By Joseph Haas

Seven weeks before its action date, Capricor got an FDA complete response for cell therapy deramiocel in DMD-related cardiomyopathy. It has a Phase III study nearing readout, though.