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Flexus flips IDO inhibitors to Bristol-Myers for up to $1.25bn

 
• By Mandy Jackson

Bristol-Myers Squibb will pay $800m up front and up to $450m in milestone fees to buy Flexus Biosciences, but all of the immunotherapy developer's assets except for its indoleamine-2,3-dioxygenase-1 (IDO-1) inhibitor program will be spun out into a new company.

Bristol-Myers Squibb will pay $800m up front and up to $450m in milestone fees to buy Flexus Biosciences, but all of the immunotherapy developer's assets except for its indoleamine-2,3-dioxygenase-1 (IDO-1) inhibitor program will be spun out into a new company.

IDO inhibitors have become hot properties for evaluation in combination regimens with other immunotherapy agents, especially with programmed cell death-1 (PD-1) inhibitors like Opdivo (nivolumab) from Bristol-Myers

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