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Shire's Alagille syndrome drug fails Phase II trial

 
• By Sukaina Virji

Shire's Phase II IMAGO trial of SHP625 in 20 pediatric patients with Alagille syndrome (ALGS) has failed to meet its primary or secondary endpoints.

Shire's Phase II IMAGO trial of SHP625 in 20 pediatric patients with Alagille syndrome (ALGS) has failed to meet its primary or secondary endpoints.

ALGS is a rare, life-threatening genetic disorder that presents in about one in 30,000 live births with chronic cholestasis (accumulation of bile acids in the liver) and

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