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GSK Looks To Cross PD-1 Gap And Leap To Next-Generation IO Backbone

 
• By Jessica Merrill

GlaxoSmithKline PLC isn't letting the fact that it doesn’t have a PD-1/L1 inhibitor get its immuno-oncology R&D efforts down. Instead, the company is focusing immuno-oncology research on next-generation checkpoint modulators, including the OX40 agonist antibody GSK3174998 and first-in-class ICOS agonist antibody GSK3359609, the company said during an R&D day in New York City Nov. 3.

GlaxoSmithKline PLC isn't letting the fact that it doesn’t have a PD-1/L1 inhibitor get its immuno-oncology R&D efforts down. Instead, the company is focusing immuno-oncology research on next-generation checkpoint modulators, including the OX40 agonist antibody GSK3174998 and first-in-class ICOS agonist antibody GSK3359609, the company said during an R&D day in New York City Nov. 3.

The immuno-oncology overview was part of a four-hour pipeline review in which management highlighted dozens of drugs in development in six core areas: HIV/infectious disease, respiratory, vaccines, immuno-inflammation, oncology and...

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