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First-Line Gazyva GALLIUM Success Bolsters Roche's CD20 Franchise

 
• By Alexandra Shimmings

Roche has caught investors off guard with the early announcement that its Phase III GALLIUM study of Gazyva in first-line follicular lymphoma has reached its primary endpoint of progression-free survival when pitted against the company's own standard-of-care treatment MabThera.

Blood cells
Blood cells • Source: Shutterstock

A pre-planned interim analysis showed the study showed that Gazyva-based therapy has already significantly reduced the risk of disease worsening or death (progression-free survival; PFS, as assessed by investigator) compared with MabThera-based treatment – a finding that has implications for the future success of the product in ameliorating the effects of upcoming biosimilar competition to the older therapy. (Also see "Sandoz Extrapolates Biosimilar Rituximab Data For EU Filing" - Scrip, 24 May, 2016.)

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