1. Scrip
  2. >>R&D

Discredited SIRT1 Stops DNA Damage In Neurons

 
• By Mark Ratner

SIRT1, the molecule activated by the controversial anti-aging supplement resveratrol, has been among the most disappointing of drug targets but now, research has linked it, along with the enzyme HDAC1, to the ability to stabilize the genome following DNA damage. The work is encouraging for the development of activators of SIRT1 and HDAC1 as neuroprotectants and DNA repair agents.

SIRT1, the molecule activated by the controversial anti-aging supplement resveratrol, has been among the most disappointing of drug targets. But now, research has linked it, along with the enzyme HDAC1, to the ability to stabilize the genome following DNA damage. The work is encouraging for the development of activators of SIRT1 and HDAC1 as neuroprotectants and DNA repair agents.

The development of small-molecule activators of SIRT1, a member of the sirtuin gene family, and a platform around sirtuin biology...

More from R&D

J&J’s Trispecific Antibody For Myeloma Offers Improved Safety, Potency Over Bispecifics

 
• By Alaric DeArment

The drugmaker presented data from its Phase I study of JNJ-79635322 at ASCO and EHA showing a 100% response rate in BCMA- and GPRC5D-naïve patients.

ASCO: Pushing The Frontiers Of ADCs

 
• By Mary Jo Laffler

Antibody-drug conjugates are a major part of the oncology pipeline, and data presented at the American Society of Clinical Oncology meeting highlight the emergence of new technologies.

Skyhawk Looks To Soar With Huntington’s Hope

 
• By Kevin Grogan

Oral RNA splicing modulator has gone into a Phase II/III trial

Scholar Rock Shows Muscle-Building PoC In Obesity

 
• By Jessica Merrill

The company said it intends to maintain a focus on rare neuromuscular disease with apitegromab but could consider partnering in obesity.

More from Scrip

China Signals Restarting IPOs For Unprofitable Biotechs

 
• By Dexter Jie Yan

The China Securities Regulatory Commission has proposed a new “growth tier” for the STAR Market of the Shanghai Stock Exchange, to reinstate the market’s listing standards for unprofitable firms.

BIO Notebook: Woodcock Calls For Doing The Right Thing, Dealmaking Remains Constrained

 
• By Mandy Jackson, Joseph Haas, and Sarah Karlin-Smith

Highlights from Day Four of the BIO International Convention include Woodcock offering practical advice on rare disease trials, the sorry state of dealmaking mid-year, Novartis discussing its approach to partnering, and Generate looking for funding to move into Phase III.

Syncona Looks To Go Private As Market Decline Deepens

 
• By Andrew McConaghie

While some are calling for Syncona to be wound up, the UK-based company believes many existing and new investors will back the creation of new private fund.