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Blueprint Medicines: A New Twist On Kinase Discovery

 
• By Michael Goodman

The convergence of maturing technology, growing industry demand for combination therapy, and regulatory innovation have given rise to Blueprint Medicines, a pure-play kinase specialist that aspires to become a US-focused cancer company.

Historically, few biopharms have focused on kinase R&D. Sugen Inc., the granddaddy of them all, generated all its considerable value well over a decade after it was acquired by Pharmacia Corp. and then Pfizer Inc. in the form of the cancer drugs Sutent (sunitinib) and Xalkori (crizotinib). In recent years, some small companies have had success: Pharmacyclics Inc. with Imbruvica (ibrutinib, a BTK inhibitor) or Incyte Corp. with Jakafi (ruxolitinib, a JAK inhibitor). But none have been wholly dedicated to kinase R&D from its founding, until recently.

Blueprint Medicines Corp. was incubated and launched by Third Rock Ventures in 2011 along with a $40 million Series...

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