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Amgen's Cancer Strategy: A Multitude Of Modalities In Immuno-Oncology And Beyond

 
• By Mandy Jackson

Amgen is the leader in approved bispecific antibodies and oncolytic viruses, but the company's not shy about expanding its oncology pipeline with even more modes of delivering medicines to cancer patients.

DNA

Like much of the biopharmaceutical industry, Amgen Inc.'s cancer drug strategy is shifting more and more toward immuno-oncology. But while it may not have a first-round checkpoint inhibitor, it has been a pioneer in at least two modes of immunotherapy. Not being married to a single therapeutic modality – antibody, small molecule, cell therapy, vaccine or otherwise – could turn out to be a long-term strength.

Thousand Oaks, California-based Amgen developed the first oncolytic virus – Imlygic (talimogene laherparepvec or T-VEC) – approved in the US. (Also see "Amgen’s Imlygic Approval A Milestone For Oncolytic Cancer Vaccines" - Pink Sheet, 27 October, 2015.) It also had the first approved bispecific T-cell engager (BiTE) antibody, Blincyto (blinatumomab). (Also see "Amgen gains early US win for BiTE antibody Blincyto" - Scrip, 4 December, 2014

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