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Regulus RNAi Candidate Can Reduce HCV Treatment To Four Weeks

 
• By Joseph Haas

Although it is on FDA clinical hold to resolve safety concerns about jaundice, RG-101 has shown the ability to significantly reduce the length – and perhaps cost – of HCV therapy when combined with current direct-acting antivirals.

BOSTON – New data on Regulus Therapeutics Inc.’s RNA interference drug RG-101, which had been submitted for presentation at the American Association for the Study of Liver Diseases meeting, show that the Phase II candidate has the efficacy to help it find a commercially viable route into the hepatitis C market, if the company can get past a clinical hold placed by FDA earlier this year.

The Phase II data showing that RG-101 in combination with direct-acting antiviral (DAA) therapy can reduce duration of treatment for...

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More from Anti-infective

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Chinese Vaccine Makers Turn To Emerging Markets

 
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More from Therapy Areas

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• By Sushmita Panda

In a turn of fortunes, Lyra Therapeutics has reported positive Phase III results for LYR-210 in chronic rhinosinusitis, boosting hopes for US approval. The company plans to submit an NDA and pursue further trials, but its cash position is precarious.

Ascletis Plans China Submission After Positive Denifanstat Phase III Acne Results

 
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New Regenxbio DMD Data Support Gene Therapy Accelerated Approval

 
• By Joseph Haas

Regenxbio reported functional and biomarker data from an ongoing study of RGX-202, which it hopes to file for approval in Duchenne muscular dystrophy in 2026.