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Madrigal Believes It Holds The Key To NASH: Clearing The Fat

 
• By Joseph Haas

Emerging Company Profile: With its first-in-class selective THR beta agonist, Madrigal thinks it may have a candidate, now in Phase II, that will offer reversal of liver damage in NASH patients with an excellent safety profile. It hopes to begin Phase III studies with MGL-3196 before the end of 2018.

Emerging Company Profile Regular column feature image Version 2

At first glance, it might seem like the last thing needed is yet another drug candidate for non-alcoholic steatohepatitis, but Madrigal Pharmaceuticals Inc. thinks its mechanism of clearing fat upstream of the processes that result in NASH may ultimately yield a drug that doctors turn to first in this as-yet unmet medical need.

Madrigal believes MGL-3916 could reverse the liver damage seen in NASH while offering a cardio-protective benefit, because the drug showed...

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