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IDO Emerges As Clean Combo Partner, Rising Star At AACR

 
• By Emily Hayes

Clean safety profile for combination of IDO inhibitors with anti-PD-1 agents in early studies presented at the American Association for Cancer Research meeting contrasts with the toxicity-laden CTLA-4/PD-1 regimen in Bristol's Phase III CheckMate 067 study.

depicting IDO mechanism of action
• Source: Bristol-Myers Squibb

New early data on IDO inhibitors from NewLink Genetics Corp. and Bristol-Myers Squibb Co. reinforce the image of the class as a safe combination partner that can enhance efficacy of PD-1 inhibitors in cancer treatment.

PD-1 immunotherapy has had an enormous impact, but only about one-third of cancer patients respond to the drugs as single agents and some tumor types don't respond at all. Bristol...

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More from Anticancer

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