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Zavante Targets Resistant Urinary Infections With I.V. Version Of Existing Drug

 
• By Joseph Haas

If approved, Zolyd will be the first intravenous epoxide antibiotic approved in the US, with greater potency than the oral version used first-line. Ex-US, the I.V. formulation has demonstrated a stable resistance profile.

Privately held Zavante Therapeutics Inc. hopes an intravenous formulation of an epoxide antibiotic first approved 20 years ago might hold the answer to addressing multi-drug resistant complicated urinary tract infections (cUTI), and now has Phase III data demonstrating non-inferiority against a control regimen of existing antibiotic combination therapy.

The San Diego biotech reported on April 6 that the ZEUS trial of Zolyd (fosfomycin) showed non-inferiority against a control...

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