PCSK9 Sponsors Still Face Challenges In Turning Around Dismal Launches

After reporting yet another quarter of disappointing sales, Amgen and Sanofi/Regeneron look forward to better performance now that outcomes data are out, but payers may not be up for easing hurdles enough.

Cholesterol plaque in artery

The first quarter of 2017 brought yet more disappointing sales figures for Amgen Inc.'s Repathaand Sanofi/Regeneron Pharmaceuticals Inc.'s Praluent, but the sponsors are hopeful for better uptake of the PCSK9 inhibitors through improved reimbursement policies on the back of new outcomes data.

Amgen reported worldwide sales of just $49m for Repatha (evolocumab) in the first quarter of 2017, which was actually down from $58m in the fourth quarter of 2016 and well under analyst expectations of $72m

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