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Janssen Enriches Crohn's Portfolio In Deal For Protagonist's Oral IL-23 Inhibitor

 
• By Mandy Jackson

J&J's Janssen committed up to $990m plus royalties to collaborate with peptide drug developer Protagonist on an oral IL-23 inhibitor for Crohn's disease, which hits a similar target as two key assets in J&J's immunology portfolio: Stelara and the Phase III biologic guselkumab.

businessman and businesswoman are shaking hands and exchanging folder after agreement was reached

Johnson & Johnson's latest investment in Crohn's disease, via a partnership between its subsidiary Janssen Biotech Inc. and Protagonist Therapeutics Inc., is a collaboration that could give the big pharma something it doesn't have for the inflammatory bowel disease: an oral drug.

Janssen committed $50m up front and up to $940m in milestone fees plus double-digit royalties for worldwide rights to Protagonist's oral peptide therapeutic PTG-200, which targets Interleukin 23 (IL-23), in all indications – including Crohn's disease and ulcerative colitis. The IL-23-focused mechanism of action is highly familiar to J&J, after its IL-12 and IL-23 inhibitor Stelara (ustekinumab) won US FDA approval in September 2016 for Crohn's disease

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