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NewLink Absorbs Big Blow As Roche Exits IDO Inhibitor Partnership

 
• By Emily Hayes

Genentech's statements about IDO as an immuno-oncology target raise questions about the future of the drug class, but IDO leader Incyte has emerged unscathed for now.

depicting IDO mechanism of action
• Source: Bristol-Myers Squibb Co.

NewLink Genetics Corp. says it will focus on development of its IDO pathway inhibitor indoximod after partner Roche walked out on a deal to develop navoximod (GDC-0919).

Indoleamine 2,3-dioxygenase (IDO1) is an enzyme that plays an important part in immune response and drugs aimed at this target have had a very high profile in recent months, due to their promise as safe agents for use in combination with PD-1/L1 inhibitors

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