Johnson & Johnson subsidiary Janssen Pharmaceutical Cos. reported a 14% reduction in the risk of major cardiovascular events for Invokana (canagliflozin) in the CANVAS outcomes trials, which was the same MACE reduction observed in the EMPA-REG trial for competing SGLT2 inhibitor Jardiance (empagliflozin), but it may be too early to declare the drugs' cardiovascular benefits – and Invokana's amputation risk – a class effect.
CANVAS Trial Results: Better For Janssen, Lilly Or the SGLT2 Class?
Janssen's Invokana reduced cardiovascular events in CANVAS on par with the MACE reduction in Lilly's and Boehringer's EMPA-REG trial for competing SGLT2 inhibitor Jardiance, but the CV benefit comes with a doubling of amputation risk versus placebo.
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