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Immuno-Oncology Outlook: Looking For Brain Cancer Options

 
• By Lucie Ellis-Taitt

Scrip analyses the potential of "hot" immunotherapy mechanisms, such as PD-1 inhibitors and CAR-T therapies, in various stages of clinical development for glioblastoma.

Thinker
Will immunotherapy combinations connect the dots to produce better outcomes in brain cancer? • Source: Shutterstock

Immunotherapy has quickly become a standard treatment option for patients with a number of tumor types, such as lung, bladder and kidney cancers, and the reach of immuno-oncology is spreading. But none of the current checkpoint inhibitors have proven effective in treating glioblastoma, a deadly form of cancer with few current treatment options and a poor survival rate.

Immuno-Oncology Outlook Series

The second in Scrip's series on immunotherapy expanding into new cancer types.

To read about the latest avenues for IO in renal cell cancer, see:

A number of companies will report clinical trial updates next year for their respective IO approaches to treating brain cancers. And while an early trial with Bristol-Myers Squibb Co.'s...

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More from Immuno-oncology

ASCO: Trodelvy First-Line TNBC Data Seen As Potentially Practice-Changing

 
• By Alaric DeArment

Gilead chief medical officer Dietmar Berger said in an interview that the company plans to quickly take the results to regulators and foresees broad first-line use of the drug.

Summit’s Ivonescimab Shows Significance On PFS, But Not Overall Survival

 
• By Joseph Haas

In a study intended to show similar benefit in western patients, PD-1/VEGF-targeting ivonescimab met a progression-free survival endpoint, but missed on OS.

Senti’s Computer-Logic Inspired Cell Therapy Shows Early Promise

 
• By Andrew McConaghie

The biotech believes its logic-gated cell therapies can get round the need for ‘clean targets’ which limit CAR-Ts and ADCs.

All Over For iTeos But Applause For Plan To Return Cash Fast

 
• By Kevin Grogan

The company has moved quickly to wind down operations after its anti-TIGIT pact with GSK collapsed.

More from Anticancer

Merck & Co./Daiichi Pull Patritumab Deruxtecan BLA On Disappointing OS

 
• By Jessica Merrill

Patritumab deruxtecan is the lead antibody drug conjugate in a $22bn deal signed between the two partners, with the decision marking a disappointing setback

Senti’s Computer-Logic Inspired Cell Therapy Shows Early Promise

 
• By Andrew McConaghie

The biotech believes its logic-gated cell therapies can get round the need for ‘clean targets’ which limit CAR-Ts and ADCs.

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• By Kevin Grogan

The company has moved quickly to wind down operations after its anti-TIGIT pact with GSK collapsed.