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Lilly, Nektar Partner On 'Stimulating' IL-2 Drug In Autoimmune Diseases

 
• By Mandy Jackson

Nektar taps into Lilly's immunology know-how for fast development of NKTR-358, which targets IL-2 to stimulate the body's own inflammation-inhibiting Tregs rather than suppress the immune system.

Business partners hands on top of each other symbolizing companionship

Nektar Therapeutics used its own expertise in targeting the interleukin-2 (IL-2) receptor for immuno-oncology to rapidly advance another novel compound with a different approach to the target, and now the company's tapping into Eli Lilly & Co.'s experience in autoimmune diseases to take NKTR-358 forward in multiple indications.

Lilly committed $150m up front and up to $250m in development and regulatory milestone fees under its deal with Nektar, which was announced July 24, plus double-digit royalties and an opportunity for the San Francisco-based firm to participate in US commercialization of NKTR-358

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