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The IO Switch: Making Tumor-Associated Macrophages Work In Our Favor

 
• By John Davis

Emerging Company Profile: Macrophage Pharma is using novel chemistry to deliver therapies directly into tumor-associated macrophages, switching their activity from immunosuppressive to immuno-stimulatory to initiate anti-tumor immune responses.

Macrophage cell
a macrophage • Source: Shutterstock

UK biotech Macrophage Pharma is a good example of how the burgeoning interest in immuno-oncology is leading to novel approaches for the treatment of cancer, in this case targeting the role of tumor-associated macrophages.

The company's technology switches the activity of such macrophages from maintaining an immunosuppressive environment around tumors to becoming immuno-stimulatory, enhancing...

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