In Hep B, Functional Cure Likely Means Two-Part Combination Process

While current HBV drugs work well to suppress the virus, combination success in HIV and HCV is leading biopharmas to seek a multi-part approach to suppressing and clearing the virus, with limited-term therapy.

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Companies working on next-generation drug therapies for hepatitis B have been talking about achieving a “functional cure” of the virus for several years now, but as candidates progress through the pipeline, consensus seems to be emerging about the best way to accomplish this.

“Functional cure” – meaning treating HBV with a temporary and largely curative regimen, similar to the drug cocktails used in HIV and hepatitis C – likely will require using an...

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