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Sanofi Expands MS Portfolio With BTK Inhibitor From Principia

 
• By Joseph Haas

The French pharma adds the Phase I candidate to its Lemtrada follow-on for multiple sclerosis development, while Principia will use $40m in upfront cash to advance its orphan disease strategy.

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Having talked up its intention to invest in neuroscience R&D, Sanofi put its money where its mouth is, agreeing to pay $40m up front to license worldwide rights to PRN2246, a Bruton’s tyrosine kinase (BTK) inhibitor just moved into clinical development by Principia BioPharma Inc. for multiple sclerosis.

While the upfront value is fairly low, Sanofi could also pay the San Francisco-area biotech milestones up to $765m and sales

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