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Seattle Genetics Diversifies Beyond ADCs With Cascadian Acquisition

 
• By Joseph Haas

The biotech already was looking to move into solid tumors, particularly breast cancer, with its antibody-drug conjugates, but now will take over a promising oral candidate in pivotal studies in HER2-positive breast cancer.

Businessman draws a statistical trend line

Seattle Genetics Inc. is finally bringing in a late-stage breast cancer candidate, a year after failing to license a different drug, by acquiring local rival Cascadian Therapeutics Inc. and its oral tyrosine kinase inhibitor (TKI) tucatinib, now in a pivotal study for patients with HER2-positive metastatic breast cancer with or without brain metastases.

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