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J&J's Apalutamide, Astellas/Pfizer's Xtandi On Par For Non-Metastatic Prostate Cancer

 
• By Emily Hayes

Phase III data at ASCO GU meeting impress, but raise questions about safety in new non-metastatic CRPC indication – rash, fractures and falls for Erleada (apalutamide) and unexplained deaths after termination of treatment for Xtandi (enzalutamide).

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Astellas Pharma Inc./Pfizer Inc.'s Xtandi (enzalutamide) and Johnson & Johnson's investigational apalutamide both demonstrated profound benefits over placebo in high-risk, non-metastatic castration resistant prostate cancer with similar results in Phase III trials, but both raised questions about safety.

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