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J&J's Apalutamide, Astellas/Pfizer's Xtandi On Par For Non-Metastatic Prostate Cancer

 
• By Emily Hayes

Phase III data at ASCO GU meeting impress, but raise questions about safety in new non-metastatic CRPC indication – rash, fractures and falls for Erleada (apalutamide) and unexplained deaths after termination of treatment for Xtandi (enzalutamide).

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Astellas Pharma Inc./Pfizer Inc.'s Xtandi (enzalutamide) and Johnson & Johnson's investigational apalutamide both demonstrated profound benefits over placebo in high-risk, non-metastatic castration resistant prostate cancer with similar results in Phase III trials, but both raised questions about safety.

Data from the PROSPER study of Xtandi and the SPARTAN study apalutamide, now dubbed Erleada, were presented on Feb. 8...

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