Incyte/Merck's ECHO-301 Failure Casts More Shadow On IDO Space

Following failure of Incyte/Merck's epacadostat/Keytruda study, NewLink Genetics says it is reviewing its IDO clinical programs.

Desperate businessmen

The Phase III failure of the combination of Incyte Corp.'s IDO inhibitor epacadostat and Merck & Co. Inc.'s Keytruda in melanoma represents another knock on the new immuno-oncology class, raising uncertainty about prospects for other IDO candidates in development.

Epacadostat is the most advanced inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), an enzyme on the tumor microenvironment that plays an...

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