Merck's Keytruda Monotherapy May Get Stuck With Small Role In First-line Lung Cancer

As results for KEYNOTE-042 are reported at ASCO, Merck's Roy Baynes says Keytruda plus chemotherapy is the standard of care in first-line non-small cell lung cancer, but Keytruda monotherapy is an option for those who don't tolerate chemo well and/or don't have very active disease.

LungCancerCells_1200x675

Merck & Co. Inc.'s PD-1 inhibitor Keytruda (pembrolizumab) as a monotherapy is likely to get a more modest slice of the first-line lung cancer pie than some hoped for, following the release of detailed data from the first-line KEYNOTE-042 study on June 3 at the American Society of Clinical Oncology meeting.

More from Immuno-oncology

Merck Gets Closer To Extending Keytruda Franchise With Subcutaneous Version

 

Merck expects Keytruda to come under Medicare price controls in 2028, but an analyst said the subcutaneous version could shield revenues for the franchise.

Rybrevant/Lazcluze Survival Win Could Overcome Tagrisso’s Convenience Advantage

 

J&J is confident that its bispecific antibody/kinase inhibitor combo’s overall survival win over AstraZeneca’s single-agent pill will shift the standard of care.

BioNTech Seeks New Partners To Boost PD-L1xVEGF Competitor

 

Increasingly focused on maximizing and accelerating the progress of its PD-L1 x VEGF inhibitor BNT357, the company expects new partnerships to be announced this year.

Sun Sets Up For PD-L1 Play With Checkpoint Acquisition

 

Sun is acquiring Checkpoint Therapeutics, opening up opportunities to build out its strategy in the onco-derm segment with the US firm’s FDA-approved anti-PD-L1 mAb.

More from Anticancer

Black Diamond Gets The Gift Of Time In License Pact With Servier

 
• By 

Servier takes a Phase I rationally designed cancer candidate for $70m up front, while Black Diamond will wait on more mature data for its Phase II lead candidate in lung cancer.

Roche Adds To Its Antibody Armoury With OBT Alliance

 
• By 

Deal Snapshot: The antibody-drug conjugate field continues one of the hottest dealmaking spaces and Roche continues to invest heavily. Its latest pact could be transformative for the UK firm which already has a decent number of big pharma partners.

AstraZeneca Buys Into In Vivo Cell Therapy Potential With EsoBiotec

 

The acquisition is worth up to $1bn and adds to AstraZeneca’s broad array of cell therapy technologies.