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Merck's Keytruda Monotherapy May Get Stuck With Small Role In First-line Lung Cancer

 
• By Emily Hayes

As results for KEYNOTE-042 are reported at ASCO, Merck's Roy Baynes says Keytruda plus chemotherapy is the standard of care in first-line non-small cell lung cancer, but Keytruda monotherapy is an option for those who don't tolerate chemo well and/or don't have very active disease.

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Merck & Co. Inc.'s PD-1 inhibitor Keytruda (pembrolizumab) as a monotherapy is likely to get a more modest slice of the first-line lung cancer pie than some hoped for, following the release of detailed data from the first-line KEYNOTE-042 study on June 3 at the American Society of Clinical Oncology meeting.

The KEYNOTE-042 study tested Keytruda as a monotherapy against combination chemotherapy in 1,274 patients with first-line non-small cell lung cancer...

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• By Alaric DeArment

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More from Anticancer

Genentech Gets Columvi Complete Response Following ODAC’s No

 
• By Joseph Haas

Seeking to move Columvi into second-line DLBCL, Genentech got an FDA letter saying the Phase III STARGLO study’s benefits may have been driven by results in Asian enrollees.

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AI-First, Big Pharma, Chinese Firms In Race - What’s Ahead For PRMT5 Inhibitors

 
• By Vibha Ravi

As AI-driven firms including Insilico, big pharmas J&J, Amgen, GSK and AstraZeneca and Chinese and Indian firms like BeOne and Dr. Reddy’s advance PRMT5 inhibitor candidates, what’s driving interest, what could lead to the first global approval and what are the challenges ahead?